/*
Theme Name: Bootstrap Basic4
Theme URI: https://rundiz.com
Author: Rundiz-WP team
Author URI: https://github.com/Rundiz-WP
Description: Bootstrap v.4 basic theme for developers to build their new theme very fast and easy. (WordPress 5 or Gutenberg ready.) The concept is to keep it basic, no rich features, no additional functions; all of these for theme developers will be easier to start develop their theme. Please read notice on Bootstrap Basic 4 Help page in Dashboard > Appearance > Bootstrap Basic4 Help.
Version: 1.3.6
Requires PHP: 5.5
Requires at least: 5.0
Tested up to: 6.9
License: MIT
License URI: https://opensource.org/licenses/MIT
Text Domain: bootstrap-basic4
Domain Path: /languages/
Tags: one-column, two-columns, three-columns, left-sidebar, right-sidebar, custom-background, custom-menu, featured-images, post-formats, threaded-comments, translation-ready, editor-style, blog

This theme built with Twitter Bootstrap v.4. It is basic theme with basic style for build new theme with Bootstrap.

*/


/*
Required WordPress CSS
*/

/*@import url('https://fonts.googleapis.com/css2?family=Noto+Sans:ital,wght@0,100..900;1,100..900&display=swap');*/
@import url('https://fonts.googleapis.com/css2?family=Noto+Sans:ital,wght@0,100..900;1,100..900&family=Zalando+Sans+SemiExpanded:ital,wght@0,200..900;1,200..900&display=swap');
body, p, h1, h2, h3, h4, h5, a, li {
    font-family: 'Noto Sans', sans-serif;
}
h1, h2, h3 {
    color: #005C9F;
    margin-bottom: 1.5rem !important;
    font-family: 'Zalando Sans SemiExpanded', sans-serif;
}
h2 {
    font-size: 2.2rem !important;
}
h3 {
    font-size: 1.3rem !important;
}
h4  {
    color: #005C9F;
    font-family: 'Zalando Sans SemiExpanded', sans-serif;
    font-size: 1.2rem !important;
}
.aligncenter {
    display: block;
    margin-right: auto;
    margin-left: auto;
    text-align: center;
}
.alignleft {
    float: left;
    margin-right: 1.5em;
}
.alignright {
    float: right;
    margin-left: 1.5em;
}
.bypostauthor {
}


/* WordPress gallery */
.gallery-caption {
}
.gallery {
    margin-bottom: 1.6em;
}
.gallery-item {
    display: inline-block;
    padding: 1.79104477%;
    text-align: center;
    vertical-align: top;
    width: 100%;
}
.gallery-columns-2 .gallery-item {
    max-width: 50%;
}
.gallery-columns-3 .gallery-item {
    max-width: 33.33%;
}
.gallery-columns-4 .gallery-item {
    max-width: 25%;
}
.gallery-columns-5 .gallery-item {
    max-width: 20%;
}
.gallery-columns-6 .gallery-item {
    max-width: 16.66%;
}
.gallery-columns-7 .gallery-item {
    max-width: 14.28%;
}
.gallery-columns-8 .gallery-item {
    max-width: 12.5%;
}
.gallery-columns-9 .gallery-item {
    max-width: 11.11%;
}
.gallery-icon img {
    margin: 0 auto;
}
.gallery-caption {
    color: #707070;
    color: rgba(51, 51, 51, 0.7);
    display: block;
    font-family: "Noto Sans", sans-serif;
    font-size: 12px;
    font-size: 1.2rem;
    line-height: 1.5;
    padding: 0.5em 0;
}
.gallery-columns-6 .gallery-caption,
.gallery-columns-7 .gallery-caption,
.gallery-columns-8 .gallery-caption,
.gallery-columns-9 .gallery-caption {
    display: none;
}


/* 
Text meant only for screen readers. 
copied from https://codex.wordpress.org/CSS
*/
.screen-reader-text {
    border: 0;
    clip: rect(1px, 1px, 1px, 1px);
    clip-path: inset(50%);
    height: 1px;
    margin: -1px;
    overflow: hidden;
    padding: 0;
    position: absolute !important;
    width: 1px;
    word-wrap: normal !important; /* Many screen reader and browser combinations announce broken words as they would appear visually. */
}
.screen-reader-text:focus {
    background-color: #f1f1f1;
    border-radius: 3px;
    box-shadow: 0 0 2px 2px rgba(0, 0, 0, 0.6);
    clip: auto !important;
    clip-path: none;
    color: #21759b;
    display: block;
    font-size: 14px;
    font-size: 0.875rem;
    font-weight: bold;
    height: auto;
    left: 5px;
    line-height: normal;
    padding: 15px 23px 14px;
    text-decoration: none;
    top: 5px;
    width: auto;
    z-index: 100000; /* Above WP toolbar. */
}


.sticky {
}
.wp-caption {
    border: 1px solid #ccc;
    margin-bottom: 1.5em;
    max-width: 100%;
}
.wp-caption img[class*="wp-image-"] {
    display: block;
    margin: 1.2% auto 0;
    max-width: 98%;
}
.wp-caption-text {
    text-align: center;
}
.wp-caption .wp-caption-text {
    margin: 0.8075em 0;
}
img {
    width: 100%;
}

.site-footer {
    background: #333;
    padding-top: 2rem;
    padding-bottom: 2rem;
    border-top: 5px solid #EBA439;;
}
.site-footer p {
    color: #fff;
    font-size: .9rem;
}
.site-footer a {
    color: #fff;
    display: block;
    font-size: .9rem;
    -moz-transition: all .3s ease-in-out;
    -o-transition: all .3s ease-in-out;
    -webkit-transition: all .3s ease-in-out;
}
.site-footer a.inline-link {
    display: inline-block;
}
.footer-col-r {
    margin-bottom: auto;
    margin-top: auto;
}
.pw-l {
    padding-left: 4rem !important;
}
.pw-r {
    padding-right: 4rem !important;
}
.pw-f {
    padding-left: 4rem !important;
    padding-right: 4rem !important;
}
#opko-med-hub-nav.navbar-nav {
    justify-content: space-around;
    width: 100%;
}
#opko-med-hub-nav.navbar-nav .nav-link {
    color: #005C9F;
    text-transform: uppercase;
    -moz-transition: all .3s ease-in-out;
    -o-transition: all .3s ease-in-out;
    -webkit-transition: all .3s ease-in-out;
}
#opko-med-hub-nav.navbar-nav .nav-link:hover {
    color: #333;
}
#opko-med-hub-nav.navbar-nav .nav-link.current-menu-item {
    border-bottom: 3px solid #eca339;
}
nav.navbar.navbar-expand-lg {
    padding-top: 1.2rem;
}
img.logo-header, img.logo-footer {
    width: 100%;
    max-width: 18rem;
    margin-top: .5rem;
}
a.blue-btn {
    background: rgba(0, 0, 0, 0);
    display: inline-block;
    font-size: 0.9rem;
    letter-spacing: 1.6px;
    font-weight: 700;
    font-family: "Noto Sans", sans-serif;
    line-height: 1;
    margin-bottom: 5px;
    text-align: center;
    text-transform: uppercase;
    white-space: normal;
    -moz-transition: all .3s ease-in-out;
    -o-transition: all .3s ease-in-out;
    -webkit-transition: all .3s ease-in-out;
    transition: all .3s ease-in-out;
    border: 2px solid #005C9F;
    color: #005C9F;
    margin: 0;
    padding: 16px 45px;
    border-radius: 30px;
    text-decoration: none;
}
a.blue-btn:hover {
    background: #005C9F;
    color: #fff;
    text-decoration: none;
}
.center {
    text-align: center;
}
.pre-head {
    background: #383838;
}
.pre-head p {
    color: #fff;
    padding-top: 0.5rem;
    font-size: .9rem;
    margin-bottom: 0.8rem;
}
.header-border {
    border-bottom: 5px solid #EBA439;
    width: 100%;
    margin: 1rem auto 0;
    box-shadow: 0 2px 8px 0 rgba(0, 0, 0, .2);
    position: relative;
    z-index: 1;
}
.italics {
    font-style: italic;
}
.bold {
    font-weight: bold;
}
.ref-well p {
    font-size: .9rem;
}
.fw-wrap {
    padding-top: 2rem;
    padding-bottom: 3rem;
}
.cta-wrap {
    /*background: #ECF3FA;*/
     /*background: linear-gradient(90deg, rgba(236, 243, 250, 1) 0%, rgb(176 212 242) 100%);*/
     position: relative;
     background: #005C9F;
     background: linear-gradient(90deg,rgba(0, 92, 159, 1) 0%, rgba(14, 125, 204, 1) 100%);
}
.cta-well h2 {
    color: #fff;
}
.cta-well a.blue-btn {
    border: 2px solid #fff;
    color: #fff;
}
.home-fw-wrap {
     /*background-color: #ecf3fa;*/
    padding-top: 0;
    padding-bottom: 0;
    background: linear-gradient(90deg, rgb(176 212 242) 0%, rgba(236, 243, 250, 1) 100%);
}
.home-hero h1 {
    padding-top: 4rem;
    font-size: 3.5rem;
}
.page-header {
    margin-bottom: 0 !important;
}
.mb-two {
    margin-bottom: 2rem;
}
.yellow-div {
    border-bottom: 1.5px solid #EBA439;
    /*width: 86%;*/
    margin: 2rem auto 0;
}
.footer-col-r {
    text-align: right;
}
#site-footer a {
    text-decoration: underline;
}
img.science-kidney-img {
    max-width: 18rem;
    padding: 2rem 0;
}
.shpt-wrap {
    /*background: #fdf2e3;*/
    padding: 2rem 2rem 1rem;
    border-radius: .4rem;
    box-shadow: 0 2px 8px 0 rgba(0, 0, 0, .1);
    margin-bottom: 2rem;
    border: 1px solid #d4d2d2;
}
table.arrow-table tr td {
    vertical-align: middle;
    padding-bottom: 1rem;
}
i.fa-duotone.fa-solid.fa-arrow-up {
    font-size: 2.5rem;
    color: #5f95d3;
}
i.fa-duotone.fa-solid.fa-arrow-down {
    font-size: 2.5rem;
    color: #eca439;
}
table.arrow-table p {
    margin-bottom: 0;
    font-size: 1.2rem;
}
.nowrap {
    text-wrap: nowrap;
}
.pt-two {
    padding-top: 2rem;
}
ul.science-list li {
    color: #eca439;
    padding-bottom: 1rem;
}
ul.science-list li:last-child {
    padding-bottom: 0.5rem;
}
span.black {
    color: #000;
}
#home-hero {
    background-image: url(/wp-content/themes/opko/images/home-hero.png);
    background-size: cover;
    background-position: 50% 50%;
    min-height: 29rem;
    box-shadow: 0 2px 8px 0 rgba(0, 0, 0, .2);
}
#science-hero {
    background-image: url(/wp-content/themes/opko/images/science-hero-2.png);
    background-size: cover;
    background-position: 50% 50%;
    min-height: 29rem;
    box-shadow: 0 2px 8px 0 rgba(0, 0, 0, .2);
}
#contact-hero {
    position: relative;
}
.science-fw-1 {
    position: relative;
    background: linear-gradient(90deg, rgb(176 212 242) 0%, rgba(236, 243, 250, 1) 100%);
}
img.science-bot-l {
    position: absolute;
    bottom: 0;
    left: -1rem;
    max-width: 30rem;
    opacity: .3;
}
#home-hero .home-hero h1, #science-hero .home-hero h1 {
    color: #fff;
    padding-top: 5rem;
    text-shadow: 0 1px 8px rgba(0, 0, 0, .3);
}
#home-hero p, #science-hero p {
    color: #fff;
    text-shadow: 0 1px 8px rgba(0, 0, 0, .3);
}
img.science-top-l {
    position: absolute;
    max-width: 30rem;
    top: -0.1rem;
    right: 0rem;
    opacity: 0.4;
}
.home-fw-wrap-2 {
    position: relative;
}
.science-content {
    background: #fff;
    padding: 2rem;
    border-radius: 1rem;
}
.cust-col-wrap, .cust-col-wrap-b {
    display: flex;
    gap: 3rem;
    align-items: center;
}
.shpt-wrap.cust-col-1 {
    min-width: 39rem;
    /*background: #f7f9fd;*/
    background: #ebeff2;
}
.shpt-wrap.cust-col-1-b {
    min-width: 35rem;
    /*background: #f7f9fd;*/
    background: #ebeff2;
    margin-bottom: auto;
    margin-top: 0rem;
}
.science-content .cust-col-2 p {
    margin-top: 2rem;
}
.mt-two {
    margin-top: 2rem;
}
.science-wrap {
    padding: 0 2rem;
}
.sciece-cta-wrap {
    text-align: center;
    padding: 1rem 0rem 1.5rem;
}
.sciece-cta-wrap h3 {
    font-size: 1.6rem !important;
    line-height: 1.5;
}
/*img.home-kidney-img {
    max-width: 18rem;
    height: auto;
    width: 100%;
    margin-top: 2rem;
}*/
img.home-kidney-img {
    max-width: 26rem;
    height: auto;
    width: 100%;
    margin-top: 2rem;
    margin-bottom: 2rem;
    background: #ebeff2;
    /*background: #f7f9fd;*/
    border: 1px solid #d4d2d2;
    border-radius: .4rem;
    box-shadow: 0 2px 8px 0 rgba(0, 0, 0, .1);
}
img.resource-tn {
    max-width: 18rem;
    margin-top: 2rem;
    width: 100%;
    height: auto;
}
.contact-detail-wrap i {
    color: #eca439;
    font-size: 2rem;
    vertical-align: -5px;
    margin-right: 0.3rem;
}
.contact-detail-wrap {
    margin-bottom: 1rem;
}
.contact-detail-wrap a {
    font-size: 1.2rem;
    color: #005C9F;
    text-decoration: underline;
    -moz-transition: all .3s ease-in-out;
    -o-transition: all .3s ease-in-out;
    -webkit-transition: all .3s ease-in-out;
}
.contact-detail-wrap a:hover {
    color: #333;
}
img.science-bot-l.contact-bot-l {
    rotate: 180deg;
}
.cta-wrap h1, .cta-wrap p {
    color: #fff;
}
.sticky-scroll {
    position: sticky;
    top: 0;
    margin-bottom: 2rem;
    padding: 1rem .5rem .5rem;
    background: linear-gradient(90deg, rgb(176 212 242) 0%, rgba(236, 243, 250, 1) 100%);
    border-bottom: .2rem solid #eaa439;
    z-index: 1;
}

.resource-btn-wrap {
    margin-top: auto;
}
.resource-col {
    display: flex;
    flex-direction: column;
    padding: 1.5rem;
    align-items: stretch;
    background: #fff;
    border-radius: .4rem;
    box-shadow: 0 2px 8px 0 rgba(0, 0, 0, .1);
    border: 0.1rem solid #015c9f;
    min-width: 0;
}
div#resource-grid {
    display: grid;
    grid-template-columns: 50% 1fr;
    gap: 2rem;
    margin: 2rem 0;
}
.resource-details p {
    margin-bottom: .5rem;
}
.resource-details {
    margin-bottom: .8rem;
    width: 100%;
}
.grid-container {
  display: grid;
  grid-template-columns: repeat(auto-fill, minmax(250px, 1fr));
  gap: 20px;
}
.disc-text {
    font-size: .9rem;
}
img.modal-logo {
    max-width: 16rem;
    display: block;
    margin: 2rem auto;
}
a.modal-x-button {
    text-align: left;
    position: absolute;
    right: 1.5rem;
    font-size: 2rem;
    color: #015ca0;
}
.btn-secondary.continue-button {
    background-color: #015c9f;
    border-color: #015c9f;
    -moz-transition: all .3s ease-in-out;
    -o-transition: all .3s ease-in-out;
    -webkit-transition: all .3s ease-in-out;
}
.btn-secondary.continue-button:hover {
    background: #333;
}
.btn-primary.cancel-button {
    background-color: #898989;
    border-color: #898989;
    -moz-transition: all .3s ease-in-out;
    -o-transition: all .3s ease-in-out;
    -webkit-transition: all .3s ease-in-out;
}
.btn-primary.cancel-button:hover {
    background: #f8dbb4;
    color: #015c9f;
}
p.lrg-text {
    font-size: 1.2rem;
}
.modal-footer {
    justify-content: center !important;
}
select,
::picker(select) {
  appearance: base-select;
}
select {
  border: 2px solid #015c9f;
  background: #fff;
  padding: 10px;
  transition: 0.4s;
  min-width: 216px;
  font-family: 'Noto Sans', sans-serif;
}

select:hover,
select:focus {
  background: #eee;
}
select::picker-icon {
    color: #015c9f;
  transition: 0.4s rotate;
}
select:open::picker-icon {
  rotate: 180deg;
}
.event-fw-1 {
    min-height: 15rem;
}
.upcoming-events-only .date-passed, .past-events-only .date-future {
    display: none;
}
div#resource-grid.event-grid {
    grid-template-columns: 33% 1fr;
}
div#resource-grid.event-grid .resource-col {
    max-width: 25.16rem;
}
div#event-grid {
    display: grid;
    gap: 2rem;
    margin: 2rem 0;
    grid-auto-rows: 1fr;
    grid-template-columns: 1fr 1fr 1fr;
}
.event-col {
    display: flex;
    flex-wrap: wrap;
    padding: 1.5rem;
    align-items: stretch;
    background: #fff;
    border-radius: .4rem;
    box-shadow: 0 2px 8px 0 rgba(0, 0, 0, .1);
    border: 0.1rem solid #015c9f;
    /*max-width: 25.16rem;*/
}
p.no-events {
    display: none;
}
#modal-hcp .modal-dialog {
    max-width: 600px;
}
.filter-col button.active {
    background: #eba339;
}
button.filter-btn {
    background: rgb(255 255 255 / 60%);
    display: inline-block;
    font-size: 0.9rem;
    font-weight: 700;
    font-family: "Noto Sans", sans-serif;
    line-height: 1;
    text-align: center;
    /* text-transform: uppercase; */
    white-space: normal;
    -moz-transition: all .3s ease-in-out;
    -o-transition: all .3s ease-in-out;
    -webkit-transition: all .3s ease-in-out;
    transition: all .3s ease-in-out;
    border: 2px solid #005C9F;
    color: #005C9F;
    margin: 1rem 0.5rem 0rem 0;
    padding: 10px 15px;
    border-radius: 30px;
    text-decoration: none;
}
/*.home-bg-img-1 {
    background-image: url(/wp-content/themes/opko/images/stock-img-2.png);
    background-size: contain;
    background-repeat: no-repeat;
    background-position: right;
   
}*/
.icon-bar {
    background: #015c9f;
    height: 4px;
    width: 2.8rem;
    display: block;
    margin-bottom: 0.5rem;
    color: transparent;
    border-color: transparent !important;
    border: none !important;
    border-radius: 0.3rem;
}
.hcp-navbar .icon-bar {
    background: #ffc107;
}
button.navbar-toggler {
    border: none;
    float: right;
    position: absolute;
    right: 0rem;
    top: 1.2rem;
}
.navbar-toggler .icon-bar:nth-of-type(1) {
  transform: rotate(45deg);
  transform-origin: 10% 10%;
}

.navbar-toggler .icon-bar:nth-of-type(2) {
  opacity: 0;
  filter: alpha(opacity=0);
}

.navbar-toggler .icon-bar:nth-of-type(3) {
  transform: rotate(-45deg);
  transform-origin: 10% 90%;
}

.navbar-toggler.collapsed .icon-bar:nth-of-type(1) {
  transform: rotate(0);
}

.navbar-toggler.collapsed .icon-bar:nth-of-type(2) {
  opacity: 1;
  filter: alpha(opacity=100);
}

.navbar-toggler.collapsed .icon-bar:nth-of-type(3) {
  transform: rotate(0);
}
.contact-wrap {
    position: relative;
    z-index: 1;
}
.site-footer a:hover {
    color: #f8dbb4;
}
@media screen and (max-width: 1350px) {
    .shpt-wrap.cust-col-1 {
        min-width: 34rem;
    }
    .science-content .cust-col-2 p {
        margin-top: 1rem;
    }
    .shpt-wrap.cust-col-1-b {
        min-width: 26rem;
    }
}
@media screen and (max-width: 1199px) {
    /*div#event-grid {
        grid-template-columns: 1fr 1fr;
    }
    div#resource-grid {
        display: flex;
    }
    .resource-col {
        display: block;
        width: 100%;
    }*/
    
    img.home-kidney-img {
        max-width: 22rem;
    }
    .resource-hero, .resource-content {
        padding-left: 2rem !important;
        padding-right: 2rem !important;
    }
    .home-hero.resource-hero h1 {
        padding-top: 2rem;
    }
}
@media screen and (max-width: 991px) {
    div#opko-nav {
        margin-top: 3rem;
    }
    #opko-med-hub-nav.navbar-nav {
        text-align: right;
        align-items: flex-end;
    }
    .pw-l {
        padding-left: 2rem !important;
    }
    .pw-r {
        padding-right: 2rem !important;
    }
    .science-wrap {
        padding: 0;
    }
    #home-hero, #science-hero {
        min-height: 0;
        padding-bottom: 2rem;
    }
    img.home-kidney-img {
        max-width: 20rem;
    }
    .science-page-content .cust-col-wrap, .science-page-content .cust-col-wrap-b {
        display: block;
    }
    .shpt-wrap.cust-col-1 {
        min-width: 0;
    }
    #home-hero .home-hero h1, #science-hero .home-hero h1 {
        padding-top: 2rem;
    }
    .filter-wrap-mb.d-md-none {
        display: flex;
        gap: 2rem;
    }
    div#resource-grid {
        display: block;
    }
    .resource-col {
        display: flex;
        width: 100%;
        gap: 2rem;
        margin-bottom: 1.5rem;
        flex-direction: row;
        align-items: center;
    }
    .resource-details {
        margin-bottom: 0;
    }
    .resource-btn-wrap {
        margin-top: 0;
    }
    .filter-wrap-mb.d-lg-none {
        display: flex;
        gap: 2rem;
    }
    div#event-grid {
        grid-template-columns: 1fr 1fr;
    }
}
@media screen and (max-width: 768px) {
    div#resource-grid {
        display: block;
    }
     .resource-col {
        display: block;
    }
    .resource-details {
        margin-bottom: .8rem;
    }
/*    .resource-col {
        display: flex;
        width: 100%;
        gap: 2rem;
        margin-bottom: 1.5rem;
        flex-direction: row;
        align-items: center;
    }
    .resource-details {
        margin-bottom: 0;
    }*/
    .resource-btn-wrap {
        margin-top: 0;
    }
    .pw-l {
        padding-left: 1rem !important;
    }
    .pw-r {
        padding-right: 1rem !important;
    }
    #home-hero {
        background-image: url(/wp-content/themes/opko/images/home-hero-mb.png);
    }
    #science-hero {
        background-image: url(/wp-content/themes/opko/images/science-hero-mb.png);
    }
    .cust-col-wrap, .cust-col-wrap-b {
        display: block;
    }
    .shpt-wrap {
        padding: 2rem 1rem 1rem;
    }
    .pw-f {
        padding-left: 2rem !important;
        padding-right: 2rem !important;
    }
    .shpt-wrap.cust-col-1-b {
        min-width: 0;
    }
    .event-col {
        margin-bottom: 1rem;
    }
    div#event-grid {
        display: block;
    }
}
@media screen and (max-width: 575px) {
   
    .home-hero h1 {
        font-size: 2rem;
    }
    .science-content {
        padding: 1rem;
    }
    .filter-wrap-mb.d-lg-none {
        display: flex;
        gap: 1rem;
        flex-wrap: wrap;
    }
}